GLENDALE, Ariz. (AP) -- Carson Palmer knew Detroit's reputation for penalties, so when he let go of his pass with the game on the line, a pass interference call was a definite possibility.
Sure enough, Lions cornerback Bill Bentley collided with receiver Andre Roberts in the end zone. A flag was thrown, a 31-yard penalty was called. It was Arizona's only third-down conversion -- in 11 tries-- of the day.
Two plays later, Rashard Mendenhall scored on a 1-yard run with 1:59 to play and the Cardinals won 25-21 on Sunday in Bruce Arians' home debut as Arizona's coach.
"It's something we talked about a lot," Palmer said. "Those DBs play the receiver, they don't play the ball, and when we have opportunities and they're staring at the receiver, they're going to face-guard. Dre (Roberts) did a great job setting that up."
Jay Feely kicked four field goals and Carson Palmer threw a 36-yard touchdown pass to rookie Andre Ellington for Arizona (1-1). Ellington, a sixth-round draft pick out of Clemson, also had a 16-yard catch to start the deciding drive.
"It's not always going to be perfect," Arians said. "You've got to learn how to ride the emotions of the game, stay with it. I thought our coaches did a great job with some adjustments in the second half and some young kids really stepped up."
Kerry Taylor, promoted from the practice squad Saturday, had three catches for 40 yards, all late in the game with Larry Fitzgerald sidelined with a sore hamstring. They were Taylor's first NFL catches.
Matthew Stafford connected with Calvin Johnson on touchdown plays of 72 and 3 yards, and DeAndre Levy returned an interception 66 yards for a score for Detroit (1-1), which led 21-13 midway through the third quarter.
Time and again, Detroit found itself starting deep in its own territory.
"I feel like we lost the field position battle today big-time," Stafford said.
The Lions were penalized eight times for 101 yards.
Detroit's Reggie Bush left the game after taking a helmet to the knee early in the second quarter, and played only briefly in the second half.
SEAHAWKS 29, 49ERS 3
At Seattle, Marshawn Lynch ran for two scores and added a seven-yard TD catch in the second half, and host Seattle flustered Colin Kaepernick into his worst passing game as a starter.
The game was delayed 60 minutes by thunderstorms late in the first quarter. The highly-anticipated NFC West showdown was sloppy as opposed to sensational, but Lynch more than did his part.
Lynch finished with 135 total yards, including 98 yards rushing, to make up for quarterback Russell Wilson hitting on just two of his first 10 throws with Seattle's receivers struggling to get open. His scoring run on the first drive of the second half gave the Seahawks a 12-0 lead and his TD catch pushed the advantage to 19-3 early in the fourth quarter.
Kaepernick was 13 of 28 for 127 yards with three interceptions for the 49ers.
SAINTS 16, BUCCANEERS 14
At Tampa, in another game delayed by lightning (69 minutes), Garrett Hartley kicked a 27-yard field goal as time expired. The Buccaneers have lost both games on last-second kicks.
"This team is a resilient team," Tampa Bay coach Greg Schiano said. "Their head coach is a resilient guy. We're going to fight our way right off it."
Linebacker Mason Foster scored on an 85-yard interception return for a 14-13 lead. But after Rian Lindell missed a 46-yard field goal, Drew Brees led the Saints back with completions of 15 yards to Jimmy Graham, 8 yards to Darren Sproles and 31 yards to Marques Colston.
Brees also was sacked four times and intercepted twice.
PACKERS 38, REDSKINS 30
At Green Bay, Aaron Rodgers threw for a career-high 480 yards and four touchdowns. James Jones had a career-high 11 catches for 178 yards. James Starks ran for 132 yards and a touchdown after rookie starter Eddie Lacy left with a concussion.
"We were able to catch the ball well, had yards after the catch and we were able to run the ball better than we have in a long time," Rodgers said.
Green Bay (1-1) built a 24-0 lead by halftime and never looked back.
Robert Griffin III threw for 320 yards and three second-half touchdowns. Pierre Garcon had 143 yards receiving and a touchdown for Washington (0-2).
BEARS 31, VIKINGS 30
At Chicago, the Bears went 2 for 2 in home-field rallies for victories. Jay Cutler threw a 16-yard touchdown pass to Martellus Bennett with 10 seconds left.
Minnesota's Blair Walsh kicked a 22-yard field goal with 3:15 remaining when Chicago took over at its 34. Cutler, who led the Bears back from an 11-point deficit in a season-opening win over Cincinnati, struck again.
Chicago moved to 2-0 under new coach Marc Trestman despite committing four turnovers. Minnesota (0-2) got 100 yards rushing from Adrian Peterson.
CHARGERS 33, EAGLES 30
At Philadelphia, the Chargers (1-1) had just as potent an offense as the Eagles' quick-hitting attack. The teams combined for 1,150 total yards, 539 for San Diego.
San Diego's unstoppable combination was Philip Rivers to Eddie Royal (three touchdowns). Nick Novak kicked a 46-yard field goal with 7 seconds left, his fourth successful kick of the game, spoiling Chip Kelly's home debut.
The Chargers punted only once, but fumbled twice inside Philadelphia's 10 in the first half.
Michael Vick threw for a career-best 428 yards and two touchdowns, and ran for a score for Philadelphia (1-1).
TEXANS 30, TITANS 24, OT
At Houston, with star receiver Andre Johnson shaken up, rookie DeAndre Hopkins was the star, catching a 3-yard touchdown pass from Matt Schaub in overtime. Hopkins reached above Jason McCourty and pulled in the pass for the Texans (2-0), who needed a franchise-record 21-point comeback to win their opener at San Diego.
On Sunday, they charged back from an eight-point, fourth-quarter deficit against the Titans (1-1). Arian Foster's 1-yard touchdown and 2-point conversion tied it at 24.
"We survived today because of some great heroics and plays by him," Texans coach Gary Kubiak said of Hopkins.
CHIEFS 17, COWBOYS 16
At Kansas City, Andy Reid won his home coaching debut as the Chiefs moved to 2-0. They won two games all of last season.
Jamaal Charles ran for 55 yards and caught a touchdown pass, and Dwayne Bowe also caught one from Alex Smith.
The Cowboys (1-1) got Dan Bailey's 53 and 30-yard field goals and Dez Bryant's 2-yard TD reception.
BILLS 24, PANTHERS 23
Rookie EJ Manuel hit a wide-open Stevie Johnson for a 2-yard touchdown pass with 2 seconds left to cap a nine-play, 80-yard drive in which the first-round draft pick completed 6 of 8 attempts for 51 yards. Manuel also got help when linebacker Luke Kuechly was penalized for pass interference with 14 seconds left.
The Panthers (0-2) lost yet another close game. They fell 12-7 to Seattle last week and are now 2-14 in games decided by seven points or fewer under coach Ron Rivera.
Host Buffalo (1-1) honored its Wall of Fame members.
DOLPHINS 24, COLTS 20
At Indianapolis, Ryan Tannehill threw for 319 yards and one touchdown as Miami (2-0) handed the Colts (1-1) their first home loss in 12 months.
Charles Clay gave Miami the lead for good with a 1-yard TD run late in the third quarter. But Andrew Luck had the Colts positioned to rally yet again after reaching the Miami 23 with 1:45 left in the game.
Luck then threw three straight incompletions and could not evade the pass rush on fourth down.
FALCONS 31, RAMS 24
At Atlanta, Julio Jones hauled in 11 passes for 182 yards, including an 81-yard touchdown.
Matt Ryan threw for 374 yards and two scores and Jason Snelling clinched it for the Falcons (1-1) with an 11-yard touchdown run, Atlanta's longest play of the day on the ground.
The Rams (1-1) fell behind 21-0 when Osi Umenyiora returned an interception 68 yards for a touchdown early in the second quarter. St Louis fought back on a pair of short touchdown passes by Sam Bradford, who finished with 352 yards and three TDs.
RAIDERS 19, JAGUARS 9
At Oakland, Darren McFadden ran for 129 yards and Oakland's defense held Jacksonville (0-2) out of the end zone until the closing minutes.
Terrelle Pryor ran for 50 yards and threw for 126 in his first home start for the Raiders (1-1), and Marcel Reece scored on an 11-yard run. Sebastian Janikowski added four field goals.