SAINTS 31, CHARGERS 24
NEW ORLEANS -- Drew Brees threw for 370 yards and broke a half-century-old NFL record by throwing a touchdown pass in his 48th straight game, and New Orleans won for the first time this season with a victory over San Diego.
Brees' 40-yard pass to Devery Henderson eclipsed the mark of 47 consecutive games with a touchdown pass set by Johnny Unitas from 1956-60. Brees' also had three scoring strikes to Marques Colston, giving him a franchise-record 52 touchdown catches with the Saints (1-4).
Philip Rivers passed for 354 yards and two touchdowns for the Chargers (3-2), but had an interception and fumble in the final quarter.
FALCONS 24, REDSKINS 17
LANDOVER, Md. -- Michael Turner ran 13 yards for the go-ahead score with 2:46 to play, and Atlanta knocked Robert Griffin III out of the game.
The Falcons are 5-0 for the first time in franchise history.
Matt Ryan completed 34 of 52 passes for 345 yards as Atlanta handed Washington (2-3) its eighth consecutive home loss.
Griffin left the game in the third quarter after being hit in the head on a sack by linebacker Sean Weatherspoon. Coach Mike Shanahan said RG3 has a "mild concussion."
Kirk Cousins took over and threw a 77-yard touchdown pass to Santana Moss to give the Redskins a fourth-quarter lead, but the fourth-round pick also threw two interceptions in the final two minutes.
PATRIOTS 31, BRONCOS 21
FOXBOROUGH, Mass. -- Tom Brady won his latest showdown with Peyton Manning with the help of a career-high 151 yards rushing from Stevan Ridley.
Brady directed four scoring marches of at least 80 yards and the Patriots rushed for 252 yards.
Brady improved to 9-4 against Manning, He completed 23 of 31 passes for 223 yards and one touchdown and ran for another. Manning was 31 of 44 for 345 yards and three touchdowns but lost a fumble on a third-quarter sack. The fumble led to Ridley's 8-yard run that put the Patriots (3-2) ahead 31-7 with about five minutes left in the third quarter.
Manning then threw touchdown passes of 2 yards to Eric Decker and 5 yards to Brandon Stokley but Denver (2-3) lost a fumble with 3:42 remaining.
STEELERS 16, EAGLES 14
PITTSBURGH -- Shaun Suisham hit a 34-yard field goal as time expired.
The Eagles (3-2) took the lead on a 2-yard touchdown pass from Michael Vick to Brent Celek with 6:33 remaining, but the Steelers responded by driving 64 yards, including a pair of key third-down conversions by quarterback Ben Roethlisberger, to set up the winning kick.
Pittsburgh running back Rashard Mendenhall ran for 81 yards and a touchdown in his first game of the season as the Steelers (2-2) avoided their first two-game losing streak in three years.
Vick completed 20 of 30 passes for 175 yards and two scores but fumbled twice for the Eagles, who couldn't keep their string of narrow early-season victories going.
VIKINGS 30, TITANS 7
MINNEAPOLIS -- Percy Harvin pounded his way through Tennessee's defense for one touchdown rushing and another receiving for Minnesota.
Harvin caught eight passes for 108 yards for the Vikings (4-1), who have given up a combined 33 points in winning three straight games. Christian Ponder threw his first two interceptions after 143 attempts without one, but he still finished 25 for 35 for 258 yards and two scores against the reeling Titans (1-4).
Matt Hasselbeck, starting in place of the injured Jake Locker, went 26 for 43 for 200 yards, one touchdown and one interception.
49ERS 45, BILLS 3
SAN FRANCISCO -- Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and San Francisco amassed a franchise-record 621 yards.
Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.
Rian Lindell kicked a 31-yard field goal in the first quarter before San Francisco scored the final 42 points to hand Buffalo (2-3) its second straight embarrassing loss.
BEARS 41, JAGUARS 3
JACKSONVILLE, Fla. -- Charles Tillman and Lance Briggs returned interceptions for touchdowns -- their second in six days -- and Chicago used stifling defense to overwhelm Jacksonville.
The Bears (4-1) scored 38 unanswered points in the second half to win their third consecutive game. The streak has everything to do with defense.
Chicago has returned five interceptions for touchdowns in the last three weeks.
The Jaguars (1-4) never recovered and played the final quarter amid a chorus of boos.
SEAHAWKS 16, PANTHERS 12
CHARLOTTE, N.C. -- Russell Wilson threw a 13-yard touchdown pass to Golden Tate with 35 seconds left in the third quarter and Seattle came up with four sacks against Cam Newton.
Wilson shook off two third quarter interceptions -- including one that was returned for a touchdown.
Wilson threw for 221 yards, while Marshawn Lynch ran for 85 yards for the Seahawks (3-2).
Newton threw for 141 yards on 12-for-29 passing, while the Panthers (1-4) managed 190 total yards.
RAVENS 9, CHIEFS 6
KANSAS CITY, Mo. -- Ray Rice ran for 101 yards and Justin Tucker made all three of his field goal attempts.
Joe Flacco threw for 187 yards and was picked off once, but the Ravens (4-1) were still able to come up with enough points to beat the Chiefs (1-4), who turned it over four times.
Matt Cassel threw for 92 yards, was intercepted twice and credited with two lost fumbles before leaving in the fourth quarter with what the Chiefs described as a head injury. Brady Quinn led Kansas City to another field goal by Ryan Succop.