ST. LOUIS (AP) -- Without his favorite target, Sam Bradford seemed lost. The top pick of the 2010 draft completed a measly seven passes.
The St. Louis Rams defense was there to pick him up -- by continually knocking down Kevin Kolb.
The Rams (3-2) totaled nine sacks, their most since 1998, in a 17-3 victory Thursday night that ended the Arizona Cardinals' early unbeaten run.
"They've played great all year," Bradford said. "They've kept us in a lot of games. Fortunately, we were able to make the big play in the fourth quarter to go up two scores, but all the credit tonight to our defense."
Danny Amendola made a spectacular one-handed grab for a 44-yard gain on an underthrown ball that set up Bradford's touchdown pass to Lance Kendricks' on the Rams' opening drive.
Bradford misfired on five consecutive passes before Amendola injured his right shoulder making a diving attempt on a 22-yarder that was initially ruled a catch but was overturned after the Cardinals challenged. Amendola used his left arm to fling his helmet on the way to the X-ray room and had his arm in a sling after the game, when he was not made available to reporters.
Bradford had six more incompletions plus an end zone interception by Patrick Peterson before ending the slump with a 52-yard touchdown pass to rookie Chris Givens for a 14-point cushion early in the fourth quarter. Givens, the fastest player on the team, had dropped a few passes earlier in the game.
The Cardinals outgained the Rams 282-242.
No changes yet for Browns
BEREA -- Jimmy Haslam III won't spend his first days as owner of the Browns handing out pink slips.
Haslam, whose $1 billion purchase of Cleveland's franchise is expected to be approved by NFL owners later this month, said Thursday through a team spokesman that he has no plans to make any personnel changes "until after the year." At 0-4, the Browns are the only winless team in the AFC, leading to speculation that coach Pat Shurmur and his staff could be in trouble unless there's a turnaround.
But during an interview with Fox Business, Haslam noted the Browns' youth -- they're the league's youngest team -- and said he believes the team is improving under Shurmur and team president Mike Holmgren.
Nicks will miss start
EAST RUTHERFORD, N.J. -- New York Giants wide receiver Hakeem Nicks won't play in Sunday's game against Cleveland because of recurring left foot and knee problems.
Nicks has missed the last two games and coach Tom Coughlin said Thursday that Nicks won't be available against the Browns. That complicates New York's passing game because backup Ramses Barden has a concussion and his status is uncertain.
Jennings will not play
GREEN BAY, Wis. -- The question is no longer whether Greg Jennings will play Sunday at Indianapolis.
Green Bay Packers coach Mike McCarthy took care of that on Thursday, ruling the two-time Pro Bowl wide receiver out with the groin injury that has nagged him all season.
Colts promote blood drive
INDIANAPOLIS -- The Indianapolis Colts plan to honor coach Chuck Pagano by selling T-shirts, handing out wristbands and promoting a blood drive.
Pagano was diagnosed last week with a form of leukemia and has been undergoing treatment at an Indianapolis hospital.
Beginning Friday, the team's pro shop will sell special edition Chuckstrong T-shirts for $20. Proceeds, team officials say, will benefit leukemia research at the Indiana University Simon Cancer Center.
Tough week for Pagono family
SAN DIEGO -- Chargers defensive coordinator John Pagano spoke publicly for the first time Thursday about his brother Chuck, the Indianapolis Colts' head coach who was diagnosed with a treatable form of Leukemia last week.
The illness became public knowledge on Monday, when it was reported Chuck Pagano would be away from his team for an indefinite period of time.